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Depression: Depression & Related Conditions
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Historical Understandings of Depression

Rashmi Nemade, Ph.D., edited by Kathryn Patricelli, MA

Depression has always been a health problem for human beings. Historical documents written by healers, philosophers, and writers throughout the ages point to the long-standing existence of depression as a health problem. They also describe the continuous and sometimes very clever struggles people have made to find effective ways to treat this condition.

open book with eyeglassesDepression was initially called "melancholia". The earliest accounts of melancholia appeared in ancient Mesopotamian texts in the second millennium B.C. At this time, all mental illnesses were thought to be caused when someone was taken over by demons (possession). They were then treated by priests. A separate class of "physicians" treated physical injuries, but not conditions like depression. The first historical understanding of depression was that depression was a spiritual or mental illness rather than a physical one.

Ancient Greeks and Romans were divided in their thinking about the causes of melancholia. Literature of the time was filled with references to mental illness caused by spirits or demons. In the 400s B.C., the Greek historian Herodotus wrote about a king who was driven mad by evil spirits. The early Babylonian, Chinese, and Egyptian civilizations also viewed mental illness as a form of demonic possession. They used exorcism techniques, such as beatings, restraint, and starvation. These "treatments" were designed to drive demons out of the afflicted person's body. In contrast, early Roman and Greek doctors thought that depression was both a biological and psychological disease. Gymnastics, massage, special diets, music, and baths, as well as a mixture of poppy extract and donkey's milk were used to treat depressive symptoms.

Hippocrates, a Greek physician, suggested that personality traits and mental illnesses were related to balanced or imbalanced body fluids called humours. There were four of these humours: yellow bile, black bile, phlegm and blood. Hippocrates classified mental illnesses into categories that included mania, melancholia (depression), and phrenitis (brain fever). Hippocrates thought that melancholia was caused by too much black bile in the spleen. He used bloodletting (a supposedly therapeutic technique which removed blood from the body), bathing, exercise, and dieting to treat depression. In contrast to Hippocrates' view, the famous Roman philosopher and statesman Cicero argued that melancholia was caused by violent rage, fear and grief. This was a mental explanation for depression rather than a physical one.

In the last years before Christ, the influence of Hippocrates faded. The predominant view among educated Romans was that mental illnesses like depression were caused by demons and by the anger of the gods. For instance, Cornelius Celsus (25BC-50 AD) recommended starvation, shackles (leg irons), and beating as "treatments." In contrast, Persian physicians such as Rhazes (865-925), the chief doctor at Baghdad hospital, continued to view the brain as the seat of mental illness and melancholia. Treatments for mental illness often involved hydrotherapy (baths) and early forms of behavior therapy (positive rewards for appropriate behavior).

After the fall of the Roman empire in the 400s AD, scientific thinking about the causes of mental illness and depression again went backward. During the Middle Ages, religious beliefs, specifically Christianity, dominated popular European explanations of mental illness. Most people thought that mentally ill people were possessed by the devil, demons, or witches. They also thought it was possible for these people to infect others with their madness. Treatments included exorcisms, and other crueler strategies such as drowning and burning. A small minority of doctors continued to believe that mental illness was caused by imbalanced bodily humors, poor diet, and grief. Some people with depression were tied up or locked away in "lunatic asylums".

The Renaissance began in Italy in the 14th century and spread throughout Europe in the 1500s and 1600s. During this time, thinking about mental illness was characterized by both forward progress and backward thinking. On the one hand, witch-hunts and executions of the mentally ill were quite common throughout Europe. On the other hand, some doctors returned to the views of Hippocrates, asserting that mental illnesses were due to natural causes, and that witches were actually mentally disturbed people in need of humane medical treatment.

In 1621, Robert Burton published Anatomy of Melancholy, in which he described the psychological and social causes of depression. These social causes included issues such as poverty, fear and social isolation. In this work, he recommended diet, exercise, distraction, travel, purgatives (cleansers that purge the body of toxins), bloodletting, herbal remedies, marriage, and even music therapy as treatments for depression.

During the beginning of the Age of Enlightenment (the 1700s and early 1800s), it was thought that depression was an inherited, unchangeable weakness of temperament. This led to the common thought that affected people should be shunned or locked up. As a result, most people with mental illnesses became homeless and poor, and some were committed to institutions.